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Cancer Chemotherapy and Pharmacology
September 2009, Volume 64, Issue 4, pp 753-761
Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice
 
Abstract
 
Purpose
Cisplatin is a widely used anti-cancer drug in the treatment of a wide range of tumors; however, its application is limited by nephrotoxicity, which is affected by oxidative stress. We have reported that molecular hydrogen (H2) acts as an efficient antioxidant (Ohsawa et al. in Nat Med 13:688–694, 2007). Here we show that hydrogen efficiently mitigates the side effects of cisplatin by reducing oxidative stress.
 
Methods
Mice were administered cisplatin followed by inhaling hydrogen gas (1% H2 in air). Furthermore, instead of inhaling hydrogen gas, we examined whether drinking water containing hydrogen (hydrogen water; 0.8 mM H2 in water) is applicable by examining oxidative stress, mortality, and body-weight loss. Nephrotoxicity was assessed by morphological changes, serum creatinine and blood urea nitrogen (BUN) levels.
 
Results
Inhalation of hydrogen gas improved mortality and body-weight loss caused by cisplatin, and alleviated nephrotoxicity. Hydrogen was detected in blood when hydrogen water was placed in the stomach of a rat. Consuming hydrogen water ad libitum also reduced oxidative stress, mortality, and body-weight loss induced by cisplatin in mice. Hydrogen water improved metamorphosis accompanying decreased apoptosis in the kidney, and nephrotoxicity as assessed by serum creatinine and BUN levels. Despite its protective effects against cisplatin-induced toxicity, hydrogen did not impair anti-tumor activity of cisplatin against cancer cell lines in vitro and tumor-bearing mice in vivo.
 
Conclusion
 
Hydrogen has potential for improving the quality of life of patients during chemotherapy by efficiently mitigating the side effects of cisplatin.
 

13-09-20 19:51
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MIT ȣ( Ventilator) 07-29 1870
22 Ҿ ܰ ġ б ǰ Ҿưб 03-17 1048
21 1 б ǰ Űб1 03-17 1884
20 ̿ñ ȯڿ Dysferlin (4) 03-17 1403
19 MIT ȣ( Ventilator) 07-29 1870
18 䳢 ô ջ Ұ ȿ (2) 04-11 4217
17 Ұ 踦 Դϴ. (2) 04-11 4661
16 Inhalation of hydrogen gas attenuates cisplatin-induced otot 10-14 3873
15 Ұ Դϴ. (1) 09-20 5493
14 Ұ ڷԴϴ. (1) 09-20 7357
13 ǰ Ͽ-4 03-13 4141
12 ǰ Ͽ-3 03-12 4500
11 ǰ Ͽ-2 03-12 3770
10 ǰ Ͽ, 03-12 3411
9 渶 ´ ִ 09-04 3483
8 ȿ(ó: ǿ) 09-04 4460
7 (ó- ǿ) 09-04 3724
6 ׻ȭ ǰ, Ȱ ſ 09-04 4794
5 ҿ 09-04 3707
4 ϴ 09-04 9727
3 Ұ ޵Ǹ ̷ п Ư ϴ. (1) 09-04 3456
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